Article
Comparison of two commercial assays for the detection of insertion mutations of HIV-1 reverse transcriptase.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 May 2001
Koch N, Tamalet C, Tivoli N, Fantini J, Yahi N
Abstract excerpt
Insertions in the beta3-beta4 fingers subdomain of HIV-1 reverse transcriptase (RT) confer cross-resistance to various nucleoside analogs. The detection of these rearrangements in the region of codons 67-70 of RT is of primary importance for adapting and optimizing combination treatment regimen. Recent reports suggest that some genotyping techniques based on the hybridization of oligonucleotide probes may fail to...
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