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Article

CD8+ lymphocytes respond to different HIV epitopes in seronegative and infected subjects

15 May 2001

Abstract excerpt

HIV-1-specific cytotoxic T-lymphocyte (CTL) responses have been detected at a low frequency in many HIV-1-exposed, persistently seronegative (HEPS) subjects. However, it is unclear how CTLs could protect against HIV acquisition in HEPS subjects, when high levels of circulating CTL fail to prevent disease progression in most seropositive subjects. To address this issue we studied CD8(+) lymphocyte responses to a...

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PMID: 11375420
DOI: 10.1172/jci12433

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