Article
A highly conserved sequence essential for translational repression of the protamine 1 messenger rna in murine spermatids.
Biology of reproduction - 1 Jun 2001
Zhong J, Peters A H, Kafer K, Braun R E
Abstract excerpt
Translational regulation of the protamine 1 mRNA is mediated by sequences in its 3' untranslated region. In this study, we demonstrate that a highly conserved sequence, the translational control element, is solely responsible for protamine 1 translational regulation. Mutation of the conserved sequence causes premature translation of a transgene containing a fusion between the human growth hormone coding sequence...
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