Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defect of lck in a patient with common variable immunodeficiency.

International journal of molecular medicine - 1 Jun 2001

Sawabe T, Horiuchi T, Nakamura M, Tsukamoto H, Nakahara K, Harashima S I, Tsuchiya T, Nakano S

Abstract excerpt

Common variable immunodeficiency (CVID) is a congenital immunological disorder characterized by defective antibody production with normal count of peripheral B lymphocytes. The basic immunologic defects that leads to CVID are still unknown, however, a proportion of CVID is suggested to be caused by decreased CD4+ helper T cell activity. In addition, recent reports indicate that a defect of T cell receptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to 5' Untranslated Regions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4 Antigens

Share to Common Variable Immunodeficiency

Share to Immunophenotyping

Share to Lymphocyte Specific Protein Tyrosine Kinase p56(lck)

Share to Lymphopenia

Share to Receptors, Antigen, T-Cell

Source

Identifiers

PMID: 11351273
DOI: 10.3892/ijmm.7.6.609

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Defect of lck in a patient with common variable immunodeficiency.PMID 11351273Read ↗

Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive LCK deficiency.Semantic proximity Read ↗

Defective expression of p56lck in an infant with severe combined immunodeficiency.Semantic proximity Read ↗

Identification of ITK deficiency as a novel genetic cause of idiopathic CD4+ T-cell lymphopenia.Semantic proximity Read ↗

LCK at the crossroad of immunodeficiency and autoimmunity: Mechanisms and therapeutic opportunities.Semantic proximity Read ↗

ICOS deficiency in patients with common variable immunodeficiency.Semantic proximity Read ↗

Novel Synonymous Variant in IL7R Causes Preferential Expression of the Soluble Isoform.Semantic proximity Read ↗

Novel compound heterozygous mutations in a Japanese girl with Janus kinase 3 deficiency.Semantic proximity Read ↗

T-cell abnormalities in common variable immunodeficiency.Semantic proximity Read ↗

Severe combined immunodeficiency caused by a splicing abnormality of the CD3delta gene.Semantic proximity Read ↗

Dysfunctional BLK in common variable immunodeficiency perturbs B-cell proliferation and ability to elicit antigen-specific CD4+ T-cell help.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.