Article
The 3T3-L1 fibroblast to adipocyte conversion is accompanied by increased expression of angiopoietin-1, a ligand for tie2.
Growth factors (Chur, Switzerland) - 1 Jan 2000
Stacker S A, Runting A S, Caesar C, Vitali A, Lackmann M, Chang J, Ward L, Wilks A F
Abstract excerpt
The tie2 receptor tyrosine kinase plays a key role in angiogenesis, and the remodeling and maturation of blood vessels. In this study we have used a factor-dependent cell line (Ba/F3) expressing a chimeric receptor containing the extracellular domain of mouse tie2 and the transmembrane and cytoplasmic domain of the erythropoietin receptor to identify specific binding activity associated with an adipogenic...
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