Article
Human skin reconstruct models: a new application for studies of melanocyte and melanoma biology.
1 Apr 2001
Abstract excerpt
Studies of melanocyte and melanoma biology using monocultures of cells are limited because of culture-induced morphology changes and expression of genes related to growth, migration, and invasion, which do not reflect the in situ phenotype of normal melanocytes, nevus cells, or melanoma cells from biologically early progression stages. The development of organotypic cultures of human skin, in which culture...
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