Article
Identification of a simian immunodeficiency virus reverse transcriptase variant with enhanced replicational fidelity in the late stage of viral infection.
The Journal of biological chemistry - 29 Jun 2001
Diamond T L, Kimata J, Kim B
Abstract excerpt
Genomic hypermutation of human and simian immunodeficiency viruses (HIV and SIV) enables these viruses to adapt and escape from various types of anti-viral selection by altering the molecular properties of viral gene products. In this study, we examined whether the biochemical and catalytic properties of SIV DNA polymerases (reverse transcriptases; RT) can change during the course of viral infection. For this...
Topics
- Amino Acid Sequence
- Animals
- Base Pair Mismatch
- DNA
- Genetic Variation
- Kinetics
- Macaca
- Molecular Sequence Data
- Mutation
- RNA
- RNA-Directed DNA Polymerase
- Sequence Homology, Amino Acid
- Simian Acquired Immunodeficiency Syndrome
- Simian Immunodeficiency Virus
- Templates, Genetic
- Virus Replication