Article
Replication of a pre-existing resistant HIV-1 subpopulation in vivo after introduction of a strong selective drug pressure.
Antiviral therapy - 1 Jan 1996
de Jong M D, Schuurman R, Lange J M, Boucher C A
Abstract excerpt
Recent reports indicate a high rate of viral replication during all phases of HIV-1 infection. This rapid turnover presents a continuous drive towards mutations in the HIV-1 genome, which may include those conferring drug resistance. Although the natural occurrence of drug-resistant variants has been reported, the implication on viral kinetics of the subsequent introduction of a selective pressure, in the form of...
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