Article
Characterization of cis-acting sequences involved in canine adenovirus packaging.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Apr 2001
Soudais C, Boutin S, Kremer E J
Abstract excerpt
The cis-acting packaging domain in adenovirus serotype 5 (Ad5) is a series of redundant, albeit not functionally equivalent, "A-repeats" made up of the consensus sequence 5'-TTTGN(8)CG-3'. A-repeats may bind trans-acting factors that direct packaging of the adenovirus genome into the preformed capsid. To try to understand this basic mechanism, we examined the packaging domain from a nonhuman adenovirus. We...
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