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Article

Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype.

AIDS (London, England) - 30 Mar 2001

Van Laethem K, Witvrouw M, Pannecouque C, Van Remoortel B, Schmit J C, Esnouf R, Kleim J P, Balzarini J, Desmyter J, De Clercq E, Vandamme A M

Abstract excerpt

OBJECTIVES: To investigate the genotypic and phenotypic effects of in vitro resistance selection with lamivudine and/or the second generation non-nucleoside reverse transcriptase inhibitor (NNRTI) quinoxaline HBY097 using HIV-1 isolates carrying the multi-nucleoside resistance pattern linked to the Q151M mutation. METHODS: Virus strains were selected in C8166 cells in the presence of increasing concentrations of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11316991
DOI: 10.1097/00002030-200103300-00003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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