Article
Phenotypic switching of nonpeptidergic cutaneous sensory neurons following peripheral nerve injury.
PloS one - 1 Jan 2011
Wang Ting, Molliver Derek C, Jing Xiaotang, Schwartz Erica S, Yang Fu-Chia, Samad Omar Abdel, Ma Qiufu, Davis Brian M
Abstract excerpt
In adult mammals, the phenotype of half of all pain-sensing (nociceptive) sensory neurons is tonically modulated by growth factors in the glial cell line-derived neurotrophic factor (GDNF) family that includes GDNF, artemin (ARTN) and neurturin (NRTN). Each family member binds a distinct GFRα family co-receptor, such that GDNF, NRTN and ARTN bind GFRα1, -α2, and -α3, respectively. Previous studies revealed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
