Article
Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder.
American journal of medical genetics - 8 Mar 2001
Greenwood T A, Alexander M, Keck P E, McElroy S, Sadovnick A D, Remick R A, Kelsoe J R
Abstract excerpt
A role for the dopamine transporter (DAT) in bipolar disorder is implicated by several lines of pharmacological evidence, as well as suggestive evidence of linkage at this locus, which we have reported previously. In an attempt to identify functional mutations within DAT contributing a susceptibility to bipolar disorder, we have screened the entire coding region, as well as significant portions of the adjacent...
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