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Article

Widely used prostate carcinoma cell lines share common origins

21 Mar 2001

Abstract excerpt

BACKGROUND: Cross-contamination is a persistent problem in the establishment and maintenance of mammalian cell lines. The observation that the cell lines PC-3, ALVA-31, and PPC-1 all have a homozygous deletion of the alpha-catenin gene prompted us to investigate the uniqueness of these and several other widely used prostate carcinoma cell lines. METHODS: The genetic backgrounds of the putative human prostate cell...

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PMID: 11304728
DOI: 10.1002/pros.1045

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