Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic risk, number of previous depressive episodes, and stressful life events in predicting onset of major depression.

The American journal of psychiatry - 1 Apr 2001

Kendler K S, Thornton L M, Gardner C O

Abstract excerpt

OBJECTIVE: The association between stressful life events and the onset of major depression decreases as the number of previous depressive episodes increases. How do genetic risk factors for major depression impact on this "kindling" phenomenon? In particular, do those at high genetic risk exhibit an increase in the speed of kindling, or are they "prekindled"? METHOD: Using discrete-time survival analysis, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Depressive Disorder
Share to Diseases in Twins
Share to Life Change Events

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Psychiatric Status Rating Scales

Share to Recurrence

Share to Registries

Share to Risk Factors

Share to Virginia

Source

Identifiers

PMID: 11282692
DOI: 10.1176/appi.ajp.158.4.582

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic risk, number of previous depressive episodes, and stressful life events in predicting onset of major depression.PMID 11282692Read ↗

Stressful life events and previous episodes in the etiology of major depression in women: an evaluation of the "kindling" hypothesis.Semantic proximity Read ↗

Stressful life events, genetic liability, and onset of an episode of major depression in women.Semantic proximity Read ↗

Causal relationship between stressful life events and the onset of major depression.Semantic proximity Read ↗

Toward a comprehensive developmental model for major depression in women.Semantic proximity Read ↗

Transition from stress sensitivity to a depressive state: longitudinal twin study.Semantic proximity Read ↗

Additive genetic risk from five serotonin system polymorphisms interacts with interpersonal stress to predict depression.Semantic proximity Read ↗

Molecular Genetic Analysis Subdivided by Adversity Exposure Suggests Etiologic Heterogeneity in Major Depression.Semantic proximity Read ↗

Disentangling the causal inter-relationship between negative life events and depressive symptoms in women: a longitudinal twin study.Semantic proximity Read ↗

Genetic markers of the stress generation model: A systematic review.Semantic proximity Read ↗

The role of life events and psychological factors in the onset of first and recurrent mood episodes in bipolar offspring: results from the Dutch Bipolar Offspring Study.Semantic proximity Read ↗

Clinical, sociodemographic, and genetic predictors of depressive episode duration in the UK BiobankSemantic proximity Read ↗

A direct test of the diathesis-stress model for depression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.