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Article

Role for nucleolin/Nsr1 in the cellular localization of topoisomerase I.

The Journal of biological chemistry - 17 Nov 2000

Edwards T K, Saleem A, Shaman J A, Dennis T, Gerigk C, Oliveros E, Gartenberg M R, Rubin E H

Abstract excerpt

Nucleolin functions in ribosome biogenesis and contains an acidic N terminus that binds nuclear localization sequences. In previous work we showed that human nucleolin associates with the N-terminal region of human topoisomerase I (Top1). We have now mapped the topoisomerase I interaction domain of nucleolin to the N-terminal 225 amino acids. We also show that the Saccharomyces cerevisiae nucleolin ortholog,...

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PMID: 10967121
DOI: 10.1074/jbc.M006628200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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