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Article

Activity of mu- and delta-opioid agonists in vas deferens from mice deficient in MOR gene.

British journal of pharmacology - 1 Apr 2001

Maldonado R, Severini C, Matthes H W, Kieffer B L, Melchiorri P, Negri L

Abstract excerpt

1. Mice lacking the mu-opioid receptor have been recently generated. Centrally mediated responses of mu-opioid agonists are suppressed whereas some of the delta-opioid responses are preserved in these mutant mice. 2. The vas deferens bioassay has been used in this study to investigate the functional activity at a peripheral level of mu- and delta-opioid agonists in mice lacking mu-opioid receptors. 3. The...

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Identifiers

PMID: 11264242
DOI: 10.1038/sj.bjp.0703966
PMCID: PMC1572701

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