Article
Is the CO adduct of myoglobin bent, and does it matter?
Accounts of chemical research - 1 Feb 2001
Spiro T G, Kozlowski P M
Abstract excerpt
Early reports of a severely bent CO adduct in myoglobin inspired the idea that heme proteins discriminate against CO, relative to O(2), via steric hindrance imposed by a distal histidine residue. Recent results showing that the bound CO is only slightly distorted do not by themselves overthrow the steric hypothesis, because the steric energy could be stored in displacements of the protein. However, experimental...
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