Article
Development of the tight-skin phenotype in immune-deficient mice.
Arthritis and rheumatism - 1 Mar 2001
Dodig T D, Mack K T, Cassarino D F, Clark S H
Abstract excerpt
OBJECTIVE: To determine if cutaneous thickening, a major phenotypic feature of the tight-skin (Tsk) mutation, could develop in an immune-deficient mouse. METHODS: Experimental crosses among different strains of mice were conducted to create mice that were genetically Tsk/+, and that were also homozgyous for a mutation at the Prkdc(scid) locus and thus lacked mature T and B lymphocytes. Skin samples prepared from...
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