Article
Genome scan of idiopathic generalized epilepsy: evidence for major susceptibility gene and modifying genes influencing the seizure type.
Annals of neurology - 1 Mar 2001
Durner M, Keddache M A, Tomasini L, Shinnar S, Resor S R, Cohen J, Harden C, Moshe S L, Rosenbaum D, Kang H, Ballaban-Gil K, Hertz S, Labar D R, Luciano D, Wallace S, Yohai D, Klotz I, Dicker E, Greenberg D A
Abstract excerpt
Idiopathic generalized epilepsy (IGE) is a common, complex disease with an almost exclusively genetic etiology but with variable phenotypes. Clinically, IGE can be divided into different syndromes. Varying lines of evidence point to the involvement of several interacting genes in the etiology of IGE. We performed a genome scan in 91 families ascertained through a proband with adolescent-onset IGE. The IGEs...
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