Article
Mast cell chymase expression and mast cell phenotypes in human rejected kidneys.
Kidney international - 1 Apr 2001
Yamada M, Ueda M, Naruko T, Tanabe S, Han Y S, Ikura Y, Ogami M, Takai S, Miyazaki M
Abstract excerpt
BACKGROUND: Mast cells (MCs) are known to participate in various types of chronic disease, but their role in chronic renal rejection is poorly understood. Recently, distinct phenotypes of MCs have been described in humans by the demonstration of one protease, chymase. Hence, we questioned whether chymase in MCs could play a role in the pathogenesis of renal rejection in humans. METHODS: We investigated MC chymase...
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