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Metabolic control of recombinant protein N‐glycan processing in NS0 and CHO cells

2 Mar 2001

Abstract excerpt

Chinese hamster ovary and murine myeloma NS0 cells are currently favored host cell types for the production of therapeutic recombinant proteins. In this study, we compared N-glycan processing in GS-NS0 and GS-CHO cells producing the same model recombinant glycoprotein, tissue inhibitor of metalloproteinases 1. By manipulation of intracellular nucleotide-sugar content, we examined the feasibility of implementing...

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PMID: 11257601
DOI: 10.1002/bit.1051

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