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Article

A new glycoengineered insect cell line with an inducibly mammalianized protein N-glycosylation pathway.

Glycobiology - 1 Mar 2012

Aumiller Jared J, Mabashi-Asazuma Hideaki, Hillar Alexander, Shi Xianzong, Jarvis Donald L

Abstract excerpt

The inability to produce recombinant glycoproteins with authentic N-glycans is a limitation of many heterologous protein expression systems. In the baculovirus-insect cell system, this limitation has been addressed by glycoengineering insect cell lines with mammalian genes encoding protein N-glycosylation functions ("glycogenes") under the transcriptional control of constitutive promoters. However, a potential...

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Identifiers

PMID: 22042767
DOI: 10.1093/glycob/cwr160
PMCID: PMC3267531

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