Article
Single nucleotide polymorphisms distinguish multiple dopamine transporter alleles in primates: implications for association with attention deficit hyperactivity disorder and other neuropsychiatric disorders.
Molecular psychiatry - 1 Jan 2001
Miller G M, De La Garza R, Novak M A, Madras B K
Abstract excerpt
The human dopamine transporter (DAT) gene contains a variable number tandem repeat (VNTR; 40 bases/3 to >11 repeats) in the 3'-untranslated region (3'-UTR), resulting in multiple alleles categorized by length. The 10-copy allele has been associated with attention deficit hyperactivity disorder (ADHD), yet it accounts for only a small proportion of symptom variance. We investigated whether the rhesus monkey DAT...
Topics
- 3' Untranslated Regions
- Alleles
- Animals
- Attention Deficit Disorder with Hyperactivity
- Base Sequence
- Brain Chemistry
- Carrier Proteins
- Cloning, Molecular
- Consensus Sequence
- Dopamine Plasma Membrane Transport Proteins
- Genotype
- Macaca mulatta