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Article

The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression.

The pharmacogenomics journal - 1 Jan 2001

Fuke S, Suo S, Takahashi N, Koike H, Sasagawa N, Ishiura S

Abstract excerpt

The human dopamine transporter (DAT1) gene contains a variable number of tandem repeats (VNTR) in its 3'-untranslated region (UTR). The linkage and association between the VNTR polymorphism of DAT1 and various neuropsychiatric disorders have been reported. We have determined the genomic structure of DAT1 genes containing 7-, 9-, 10-, and 11-repeat alleles and examined the effect of VNTR polymorphism in the 3'-UTR...

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Identifiers

PMID: 11911442
DOI: 10.1038/sj.tpj.6500026

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