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Article

Pancreatic B-Cell Defects in Gestational Diabetes: Implications for the Pathogenesis and Prevention of Type 2 Diabetes

1 Mar 2001

Abstract excerpt

Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia that results from tissue resistance to the glucose-lowering effects of insulin and inadequate pancreatic B-cell compensation for that resistance (1). Longitudinal studies of people at risk for T2DM reveal that insulin resistance is often present years before the onset of hyperglycemia (2–4). Studies of the evolution of diabetes during a relatively...

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PMID: 11238474
DOI: 10.1210/jcem.86.3.7339

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