Article
Nucleotide excision repair gene XPD polymorphisms and genetic predisposition to melanoma.
Carcinogenesis - 1 Mar 2001
Tomescu D, Kavanagh G, Ha T, Campbell H, Melton D W
Abstract excerpt
The nucleotide excision repair pathway has evolved to deal with UV light-induced DNA damage. Individuals with the rare inherited nucleotide excision repair deficiency disease xeroderma pigmentosum have a 1000-fold increased incidence of skin cancer. We are interested in the possibility that more subtle changes in nucleotide excision repair genes, resulting in either a reduced capacity for repair or in altered...
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