Article
Loss of aggression, after transfer onto a C57BL/6J background, in mice carrying a targeted disruption of the neuronal nitric oxide synthase gene.
Behavior genetics - 1 Sept 2000
Le Roy I, Pothion S, Mortaud S, Chabert C, Nicolas L, Cherfouh A, Roubertoux P L
Abstract excerpt
Phenotypic differences among mice with disrupted genes and those with wild-type alleles have not provided the necessary evidence for desired gene/phenotype correlations. These differences could be due to "passenger genes" from the donor 129 strains that are used to produce stem cells. Three variations of attack behavior were measured, using mice carrying a disruption of the neural nitric oxide synthase gene. In...
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