Article
A sodium-channel mutation causes isolated cardiac conduction disease.
Nature - 22 Feb 2001
Tan H L, Bink-Boelkens M T, Bezzina C R, Viswanathan P C, Beaufort-Krol G C, van Tintelen P J, van den Berg M P, Wilde A A, Balser J R
Abstract excerpt
Cardiac conduction disorders slow the heart rhythm and cause disability in millions of people worldwide. Inherited mutations in SCN5A, the gene encoding the human cardiac sodium (Na+) channel, have been associated with rapid heart rhythms that occur suddenly and are life-threatening; however, a chief function of the Na+ channel is to initiate cardiac impulse conduction. Here we provide the first functional...
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