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Article

Japanese familial patients with male-limited precocious puberty.

Endocrine journal - 1 Dec 2000

Shinagawa T, Katsumata N, Sato N, Horikawa R, Tanae A, Tanaka T

Abstract excerpt

Familial male-limited precocious puberty (FMPP) is a rare disease caused by constitutively activating mutations in the luteinizing hormone receptor (LH-R) gene. In the present study, we analyzed the LH-R gene in members of a Japanese FMPP family. Two males of the family were affected and had a heterozygous M398T mutation; one patient developed pubertal signs as early as 2 years of age, and the other at 6 years of...

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Identifiers

PMID: 11228053
DOI: 10.1507/endocrj.47.777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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