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Article

Metapopulation extinction caused by mutation accumulation.

Proceedings of the National Academy of Sciences of the United States of America - 27 Feb 2001

Higgins K, Lynch M

Abstract excerpt

Theory suggests that the risk of extinction by mutation accumulation can be comparable to that by environmental stochasticity for an isolated population smaller than a few thousand individuals. Here we show that metapopulation structure, habitat loss or fragmentation, and environmental stochasticity can be expected to greatly accelerate the accumulation of mildly deleterious mutations, lowering the genetic...

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Identifiers

PMID: 11226343
DOI: 10.1073/pnas.031358898
PMCID: PMC30242

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