Tipping the mutation-selection balance: Limited migration increases the frequency of deleterious mutants.

Abstract excerpt

Typical mutation-selection models assume well-mixed populations, but dispersal and migration within many natural populations is spatially limited. Such limitations can lead to enhanced variation among locations as different types become clustered in different places. Such clustering weakens competition between unlike types relative to competition between like types; thus, the rate by which a fitter type displaces...

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