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Article

The BRCA2 genetic variant IVS7 + 2T-->G is a mutation.

Journal of human genetics - 1 Jan 2000

Pyne M T, Brothman A R, Ward B, Pruss D, Hendrickson B C, Scholl T

Abstract excerpt

Biochemical and genetic characterizations that support the conclusion that the variant BRCA2 IVS7 + 2T --> G represents a deleterious mutation are presented. RNA analysis from a breast cancer patient with BRCA2 IVS7 + 2T --> G showed that the productive message was produced from only one chromosome. A haplotype analysis confirmed that the intronic variant resides on the chromosome that does not produce the normal...

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Source

Identifiers

PMID: 11185744
DOI: 10.1007/s100380070007

Genes

BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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