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Article

cDNA analysis demonstrates that the BRCA2 intronic variant IVS4-12del5 is a deleterious mutation.

Mutation research - 26 Apr 2009

Zhang Liying, Bacares Ruben, Boyar Sherry, Hudis Clifford, Nafa Khedoudja, Offit Kenneth

Abstract excerpt

Mutation screening of the breast and ovarian cancer predisposition genes BRCA1 and BRCA2 is becoming an increasingly important part of clinical practice. Classification of rare non-truncating sequence variants in the BRCA1 and BRCA2 genes is problematic because it is not known whether these subtle changes alter function sufficiently to predispose cells to cancer development. Several studies have reported the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19070627
DOI: 10.1016/j.mrfmmm.2008.11.010

Genes

BRCA2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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cDNA analysis demonstrates that the BRCA2 intronic variant IVS4-12del5 is a deleterious mutation.PMID 19070627Read ↗

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