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Article

The silent mutation nucleotide 744 G --> A, Lys172Lys, in exon 6 of BRCA2 results in exon skipping.

Breast cancer research and treatment - 1 Feb 2010

Hansen Thomas V O, Steffensen Ane Y, Jønson Lars, Andersen Mette K, Ejlertsen Bent, Nielsen Finn C

Abstract excerpt

Germ-line mutations in BRCA2 predispose to breast and ovarian cancer. Mutations are widespread throughout the gene and include disease-causing mutations as frameshift, nonsense, splicing mutations and large genomic rearrangements. However a large number of mutations, including missense, silent and intron variants are of unknown significance. Here, we describe the functional characterization of a silent mutation...

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Identifiers

PMID: 19267246
DOI: 10.1007/s10549-009-0359-4

Genes

BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The silent mutation nucleotide 744 G --> A, Lys172Lys, in exon 6 of BRCA2 results in exon skipping.PMID 19267246Read ↗

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