Article
Hormone replacement therapy, prothrombotic mutations, and the risk of incident nonfatal myocardial infarction in postmenopausal women.
JAMA - 21 Feb 2001
Psaty B M, Smith N L, Lemaitre R N, Vos H L, Heckbert S R, LaCroix A Z, Rosendaal F R
Abstract excerpt
CONTEXT: Estrogens are known to be prothrombotic, and findings from the Heart and Estrogen/progestin Replacement Study suggest that in women with clinically recognized heart disease, hormone replacement therapy (HRT) may be associated with early harm and late benefit in terms of coronary events. OBJECTIVE: To assess whether, as hypothesized, prothrombotic mutations modify the association between HRT use and...
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