Article
Interaction of coagulation defects and cardiovascular risk factors: increased risk of myocardial infarction associated with factor V Leiden or prothrombin 20210A.
Circulation - 24 Mar 1998
Doggen C J, Cats V M, Bertina R M, Rosendaal F R
Abstract excerpt
BACKGROUND: A genetic variation located in the 3'-untranslated region of the prothrombin gene (prothrombin 20210 G-->A) was recently described as a risk factor for venous thrombosis. We examined how the presence of this mutation affected the risk of myocardial infarction in a population-based cas...
Topics
- Adult
- Blood Coagulation Disorders
- Cardiovascular Diseases
- Case-Control Studies
- Factor V
- Gene Frequency
- Genetic Variation
- Humans
- Male
- Middle Aged
- Myocardial Infarction
- Odds Ratio
- Point Mutation
- Prothrombin
- Risk Factors
- Thrombosis