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Persistent hyperinsulinemic hypoglycemia and maturity-onset diabetes of the young due to heterozygous HNF4A mutations.

Diabetes - 1 Jun 2008

Kapoor Ritika R, Locke Jonathan, Colclough Kevin, Wales Jerry, Conn Jennifer J, Hattersley Andrew T, Ellard Sian, Hussain Khalid

Abstract excerpt

OBJECTIVE: Mutations in the human HNF4A gene encoding the hepatocyte nuclear factor (HNF)-4alpha are known to cause maturity-onset diabetes of the young (MODY), which is characterized by autosomal-dominant inheritance and impaired glucose-stimulated insulin secretion from pancreatic beta-cells. HNF-4alpha has a key role in regulating the multiple transcriptional factor networks in the islet. Recently,...

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Identifiers

PMID: 18268044
DOI: 10.2337/db07-1657

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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