Sensitization by 5‐aza‐2′‐deoxycytidine of leukaemia cells with <i>MLL</i> abnormalities to induction of differentiation by all‐<i>trans</i> retinoic acid and 1α,25‐dihydroxyvitamin D₃

Abstract excerpt

Most chromosomal abnormalities associated with breakage at 11q23 in acute leukaemia involve the MLL gene, and the presence of this breakage strongly predicts a poor clinical outcome. We assessed the possibility of differentiation-inducing therapy for acute leukaemias with chromosomal translocations involving 11q23. Among the cell lines with MLL translocations that we examined, KOCL48 and KOPN-1 cells were induced...

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