Article
Immunohistochemistry and molecular detection of nodal micrometastases in pancreatic cancer.
The Journal of surgical research - 1 Feb 2001
Brown H M, Ahrendt S A, Komorowski R A, Doffek K M, Wilson S D, Demeure M J
Abstract excerpt
PURPOSE: Assays based on polymerase chain reaction (PCR) demonstrate mutated Kiras in the regional nodes of a majority of patients with node-negative stage I or II (T(1-3), N(0), M(0)) pancreatic adenocarcinoma. The hypothesis that the presence of mutated Kiras equates with micrometastases has not been validated by detailed histologic examination nor has an impact on survival been demonstrated. METHODS: We...
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