Article
Line probe assay for detection of human immunodeficiency virus type 1 mutations conferring resistance to nucleoside inhibitors of reverse transcriptase: comparison with sequence analysis.
Journal of clinical microbiology - 1 Jul 1998
Descamps D, Calvez V, Collin G, Cécille A, Apetrei C, Damond F, Katlama C, Matheron S, Huraux J M, Brun-Vézinet F
Abstract excerpt
We compared the line probe assay (LiPA) to sequence analysis for the detection of mutations conferring resistance to nucleoside inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). Plasma samples from 40 patients who had received zidovudine, dideoxyinosine, and di...
Topics
- Anti-HIV Agents
- DNA, Viral
- Drug Resistance, Microbial
- HIV Infections
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Molecular Probe Techniques
- Mutation
- RNA, Viral
- Reverse Transcriptase Inhibitors
- Sequence Analysis, DNA