Article
Role of the line probe assay INNO-LiPA HBV DR and ultradeep pyrosequencing in detecting resistance mutations to nucleoside/nucleotide analogues in viral samples isolated from chronic hepatitis B patients.
The Journal of general virology - 1 Dec 2013
Mese Sevim, Arikan Muzaffer, Cakiris Aris, Abaci Neslihan, Gumus Ergun, Kursun Olcay, Onel Derya, Ustek Duran, Kaymakoglu Sabahattin, Badur Selim, Yenen Osman Sadi, Bozkaya Emel
Abstract excerpt
Despite the effectiveness of nucleoside/nucleotide analogues in the treatment of chronic hepatitis B (CHB), their long-term administration is associated with the emergence of resistant hepatitis B virus (HBV) mutants. In this study, mutations resulting in antiviral resistance in HBV DNA samples isolated from 23 CHB patients (nine treatment naïve and 14 treated previously) were studied using a line probe assay...
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