Article
Evaluation of mixtures of wild-type HIV-1 and HIV-1 with resistance point mutations against reverse transcriptase inhibitors.
Antiviral therapy - 1 Jan 1998
Villahermosa M L, Contreras G, Pérez-Alvarez L, Bru F, Medrano L, Delgado E, Colomo C, Thomson M, Nájera R
Abstract excerpt
The presence of resistance-related mutations in 185 serial proviral DNA samples from 108 HIV-infected patients was monitored using the line probe assay (LiPA). The proportions of wild-type and mutant virus in each sample were determined. Subsequent samples from the same patient were analysed. Resistance mutations were detected in 58 of 108 patients studied (53.7%), 53 of 73 (72.6%) treated with antivirals and 5...
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