Article
Mutations of the cardiac ryanodine receptor (RyR2) gene in familial polymorphic ventricular tachycardia.
Circulation - 30 Jan 2001
Laitinen P J, Brown K M, Piippo K, Swan H, Devaney J M, Brahmbhatt B, Donarum E A, Marino M, Tiso N, Viitasalo M, Toivonen L, Stephan D A, Kontula K
Abstract excerpt
BACKGROUND: Familial polymorphic ventricular tachycardia is an autosomal-dominant, inherited disease with a relatively early onset and a mortality rate of approximately 30% by the age of 30 years. Phenotypically, it is characterized by salvoes of bidirectional and polymorphic ventricular tachycardias in response to vigorous exercise, with no structural evidence of myocardial disease. We previously mapped the...
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