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Article

Ontogeny of telomerase in chicken: Impact of downregulation on pre‐ and postnatal telomere length<i>in vivo</i>

1 Dec 2000

Abstract excerpt

Telomeres are the termini of linear chromosomes composed of tandem repeats of a conserved DNA sequence. Telomerase provides a mechanism for proliferating cells to offset telomeric sequence erosion by synthesizing new repeats onto the end of each parental DNA strand. Reduced or absent telomerase activity can lead to telomere shortening and genome instability. Telomeres and telomerase have not previously been...

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PMID: 11142683
DOI: 10.1046/j.1440-169x.2000.00540.x

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