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Article

A helper phage to improve single-chain antibody presentation in phage display.

Nature biotechnology - 1 Jan 2001

Rondot S, Koch J, Breitling F, Dübel S

Abstract excerpt

We show here that the number of single-chain antibody fragments (scFv) presented on filamentous phage particles generated with antibody display phagemids can be increased by more than two orders of magnitude by using a newly developed helper phage (hyperphage). Hyperphage have a wild-type pIII phenotype and are therefore able to infect F(+) Escherichia coli cells with high efficiency; however, their lack of a...

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Identifiers

PMID: 11135557
DOI: 10.1038/83567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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