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Article

Increased mutation frequency of feline immunodeficiency virus lacking functional deoxyuridine-triphosphatase.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1995

Lerner D L, Wagaman P C, Phillips T R, Prospero-Garcia O, Henriksen S J, Fox H S, Bloom F E, Elder J H

Abstract excerpt

Feline immunodeficiency virus (FIV) encodes the enzyme deoxyuridine-triphosphatase (DU; EC 3.6.1.23) between the coding regions for reverse transcriptase and integrase in the pol gene. Here, we report the in vivo infection of cats with a DU- variant of the PPR strain of FIV and compare its growth properties and tissue distribution with those of wild-type FIV-PPR. The results reveal several important points: (i)...

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Identifiers

PMID: 7638216
DOI: 10.1073/pnas.92.16.7480
PMCID: PMC41363

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