Article
Increased mutation frequency of feline immunodeficiency virus lacking functional deoxyuridine-triphosphatase.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1995
Lerner D L, Wagaman P C, Phillips T R, Prospero-Garcia O, Henriksen S J, Fox H S, Bloom F E, Elder J H
Abstract excerpt
Feline immunodeficiency virus (FIV) encodes the enzyme deoxyuridine-triphosphatase (DU; EC 3.6.1.23) between the coding regions for reverse transcriptase and integrase in the pol gene. Here, we report the in vivo infection of cats with a DU- variant of the PPR strain of FIV and compare its growth...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Capsid
- Cats
- DNA Primers
- DNA, Viral
- Feline Acquired Immunodeficiency Syndrome
- Genes, pol
- Genome, Viral
- Immunodeficiency Virus, Feline
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction