Article
Proto-oncogene Raf-1 as an autoantigen in Meniere's disease.
The Annals of otology, rhinology, and laryngology - 1 Dec 2000
Cheng K C, Matsuoka H, Lee K M, Kim N, Krug M S, Kwon S S, Mora M, Yoo T J
Abstract excerpt
The 28 kd protein extracted from the guinea pig inner ear membranous fraction, which reacted with sera from patients with Meniere's disease, has been subjected to microsequencing. Nineteen amino acids were obtained (IVQQFGFQRRASDDGKLTQ). A protein data bank search showed that this sequence corresponded to residues 41 to 60 of human Raf-1 protein. Sera from 16 of 27 patients with Meniere's disease showed...
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