Article
Comparative genome analysis of the mouse imprinted gene impact and its nonimprinted human homolog IMPACT: toward the structural basis for species-specific imprinting.
Genome research - 1 Dec 2000
Okamura K, Hagiwara-Takeuchi Y, Li T, Vu T H, Hirai M, Hattori M, Sakaki Y, Hoffman A R, Ito T
Abstract excerpt
Mouse Impact is a paternally expressed gene encoding an evolutionarily conserved protein of unknown function. Here we identified IMPACT, the human homolog of Impact, on chromosome 18q11. 2-12.1, a region syntenic to the mouse Impact locus. IMPACT was expressed biallelically in brain and in various tissues from two informative fetuses and in peripheral blood from an informative adult. To reveal the structural...
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