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Article

Impaired neural regulation of insulin secretion related to the leptin receptor gene mutation in Wistar fatty rats.

Physiology & behavior - 15 Sept 2000

Ohnuma H, Yamatani K, Daimon M, Igarashi M, Manaka H, Sasaki H, Kato T

Abstract excerpt

The Wistar fatty (WF) rat is a model of obese Type 2 diabetes mellitus (DM). These rats were bred by crossing Zucker fatty (ZF) and Wistar-Kyoto (WKY) rats. A homo-allelic leptin receptor gene mutation has been reported in ZF rats. We report here how these genetic factors contribute to plasma insulin regulation. The fasting plasma insulin levels were higher in WKY and Wistar lean (WL) rats than in Zucker lean...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11111007
DOI: 10.1016/s0031-9384(00)00297-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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