Article
Impaired neural regulation of insulin secretion related to the leptin receptor gene mutation in Wistar fatty rats.
Physiology & behavior - 15 Sept 2000
Ohnuma H, Yamatani K, Daimon M, Igarashi M, Manaka H, Sasaki H, Kato T
Abstract excerpt
The Wistar fatty (WF) rat is a model of obese Type 2 diabetes mellitus (DM). These rats were bred by crossing Zucker fatty (ZF) and Wistar-Kyoto (WKY) rats. A homo-allelic leptin receptor gene mutation has been reported in ZF rats. We report here how these genetic factors contribute to plasma insulin regulation. The fasting plasma insulin levels were higher in WKY and Wistar lean (WL) rats than in Zucker lean...
Topics
- Animals
- Atropine Derivatives
- Blood Glucose
- Carrier Proteins
- Crosses, Genetic
- Diabetes Mellitus
- Diabetes Mellitus, Experimental
- Diabetes Mellitus, Type 2
- Disease Models, Animal
- Glucagon
- Glucagon-Like Peptide 1
- Glucose Tolerance Test
- Injections, Intraventricular