True epithelial hyperplasia in the thymus of early-onset myasthenia gravis patients: implications for immunopathogenesis.

doi:10.1016/s0165-5728(00)00415-x

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Article

True epithelial hyperplasia in the thymus of early-onset myasthenia gravis patients: implications for immunopathogenesis.

Journal of neuroimmunology - 1 Jan 2001

Roxanis I, Micklem K, Willcox N

Abstract excerpt

The early-onset myasthenia gravis (EOMG) thymus shows characteristic medullary epithelial bands (MEB), greatly expanded perivascular infiltrates and fenestrations of the intervening basement membranes. We now compare epithelial expression of epidermal growth factor receptor (EGFR) and many integrins in EOMG and control samples. The main differences are striking/consistent thickening (in MEB) of what is normally a...

Topics

Adolescent
Adult
Cell Movement
Child
Epithelial Cells
ErbB Receptors
Extracellular Matrix Proteins
Female
Humans
Hyperplasia
Integrins
Male
Myasthenia Gravis
Phenotype
Thymus Gland

Source

Open in PubMed

Identifiers

PMID: 11108945
DOI: 10.1016/s0165-5728(00)00415-x

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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